منابع مشابه
Use of Anticonvulsants During Pregnancy: Teratogenic Risks
The chapter summarizes literature on the teratogenic effects of anticonvulsants and presents data from the Swedish Medical Birth Register. Many anticonvulsants have a teratogenic effect which varies between individual drugs with the highest risk associated with the use of valproic acid and probably topiramide. For some much used drugs like carbamazepine and lamotrigine the risk is not much elev...
متن کاملNeuropsychological Effects of Anticonvulsants
Investigators from 7 centers in Korea conducted a prospective, multicenter study with patients randomized into two open-label, parallel groups and treated with either levetiracetam (LVT) or carbamazepine (CBZ) monotherapy for newly diagnosed focal epilepsy.
متن کاملIatrogenic nutritional effects of anticonvulsants.
The three major anticonvulsants currently used for the treatment of grand ma1 and focal epilepsy are phenobarbitone (introduced into therapy in 1912), diphenylhydantoin (DPII) (introduced in 1938), and primidone (introduced in 1952). Fig. I illustrates the common structural features of these drugs, which presumably account for their common anticonvulsant properties and side-effects. There are s...
متن کاملTeratogenic Effects of Pregabalin in Mice
Objective(s): Anti-epileptic drugs (AEDs) have the potential to affect fetal development throughout pregnancy. Considering the broad therapeutic indications of pregabalin (PGB), its potential teratogenic effects and the levels of homocysteine have been studied. Materials and Methods: Timed-pregnant mice received one of three doses of PGB (20, 40 or 80 mg/kg/day) or the vehicl...
متن کاملTeratogenic effects of antiepileptic drugs
The use of older generation antiepileptic drugs (AEDs) during pregnancy is known to be associated with a two- to threefold increased risk of birth defects in the offspring and possible also other adverse outcomes in the exposed infant. Much less has been known about newer generation AEDs in this respect. Recent studies based on national registries as well as specific epilepsy and pregnancy regi...
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ژورنال
عنوان ژورنال: BMJ
سال: 1971
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.4.5784.430-b